| John Finnegan | 12 | Blueprint for Murder, The Most Dangerous Match, Lovely But Lethal, A Friend in Deed and 8 more |
| Bruce Kirby | 8 | Lovely But Lethal, By Dawn’s Early Light, A Deadly State of Mind, Identity Crisis and 4 more |
| Mike Lally | 8 | Requiem for a Falling Star, Double Exposure, Mind Over Mayhem, Swan Song and 4 more |
| Shera Danese | 6 | Fade in to Murder, Murder Under Glass, Murder, A Self Portrait, Columbo and the Murder of a Rock Star and 2 more |
| Vito Scotti | 6 | Any Old Port in a Storm, Candidate for Crime, Swan Song, Negative Reaction and 2 more |
| Ed McCready | 5 | Rest in Peace, Mrs. Columbo, Death Hits the Jackpot, A Bird in the Hand…, It's All in the Game and 1 more |
| Bob Harks | 4 | A Stitch in Crime, Any Old Port in a Storm, A Case of Immunity, Now You See Him |
| Charles D. Miller | 4 | Agenda for Murder, Columbo Goes to College, Caution: Murder Can Be Hazardous to Your Health, Columbo and the Murder of a Rock Star |
| Dianne Turley Travis | 4 | Double Exposure, Mind Over Mayhem, A Friend in Deed, Death Hits the Jackpot |
| Fred Draper | 4 | Lovely But Lethal, A Deadly State of Mind, Last Salute to the Commodore, Fade in to Murder |
| Gerry Okuneff | 4 | Death Hits the Jackpot, A Bird in the Hand…, It's All in the Game, Strange Bedfellows |
| Jerome Guardino | 4 | Forgotten Lady, Try and Catch Me, Make Me a Perfect Murder, Murder, Smoke and Shadows |
| Patrick McGoohan | 4 | By Dawn’s Early Light, Identity Crisis, Agenda for Murder, Ashes to Ashes |
| Robert Culp | 4 | Death Lends a Hand, The Most Crucial Game, Double Exposure, Columbo Goes to College |
| Steven Gilborn | 4 | Uneasy Lies the Crown, Columbo Goes to College, Caution: Murder Can Be Hazardous to Your Health, Columbo and the Murder of a Rock Star |
| Val Avery | 4 | Dead Weight, The Most Crucial Game, A Friend in Deed, Identity Crisis |
| Alan Fudge | 3 | Publish or Perish, Columbo Goes to the Guillotine, Columbo Goes to College |
| Arlene Martel | 3 | The Greenhouse Jungle, Double Exposure, A Friend in Deed |
| Bill Zuckert | 3 | Negative Reaction, A Case of Immunity, Murder in Malibu |
| Charles Macaulay | 3 | Ransom for a Dead Man, Etude in Black, Mind Over Mayhem |
| Cliff Carnell | 3 | Blueprint for Murder, The Most Crucial Game, Identity Crisis |
| Cosmo Sardo | 3 | Double Exposure, A Friend in Deed, A Case of Immunity |
| Dennis Robertson | 3 | Double Exposure, Mind Over Mayhem, An Exercise in Fatality |
| Harvey Gold | 3 | Negative Reaction, Forgotten Lady, A Case of Immunity |
| Jack Cassidy | 3 | Murder by the Book, Publish or Perish, Now You See Him |
| Jimmy Joyce | 3 | Blueprint for Murder, Last Salute to the Commodore, Fade in to Murder |
| John Petlock | 3 | Murder in Malibu, A Bird in the Hand…, It's All in the Game |
| Manuel DePina | 3 | The Most Dangerous Match, Double Exposure, An Exercise in Fatality |
| Milt Kogan | 3 | Make Me a Perfect Murder, Columbo Goes to the Guillotine, Grand Deceptions |
| Morgan Jones | 3 | Columbo Cries Wolf, Uneasy Lies the Crown, Columbo Goes to College |
| Ray Ballard | 3 | Suitable for Framing, The Most Dangerous Match, Mind Over Mayhem |
| Richard Stahl | 3 | The Most Crucial Game, Lovely But Lethal, Double Exposure |
| Robert Donner | 3 | Any Old Port in a Storm, Caution: Murder Can Be Hazardous to Your Health, Undercover |
| Stewart J. Zully | 3 | Murder, Smoke and Shadows, Sex and the Married Detective, It's All in the Game |
| Timothy Carey | 3 | Ransom for a Dead Man, Dead Weight, Fade in to Murder |
| Victor Izay | 3 | An Exercise in Fatality, Now You See Him, Fade in to Murder |
| Alice Backes | 2 | Negative Reaction, A Trace of Murder |
| Alma Beltran | 2 | Double Exposure, A Friend in Deed |
| Anne Francis | 2 | Short Fuse, A Stitch in Crime |
| Barbara Rhoades | 2 | Lady in Waiting, Identity Crisis |
| Bart Burns | 2 | Requiem for a Falling Star, Playback |
| Ben Frommer | 2 | A Friend in Deed, A Case of Immunity |
| Bernard Fox | 2 | Dagger of the Mind, Troubled Waters |
| Bernie Kuby | 2 | Murder by the Book, A Friend in Deed |
| Bill Edward Rogers | 2 | Columbo Cries Wolf, Rest in Peace, Mrs. Columbo |
| Bob Dishy | 2 | The Greenhouse Jungle, Now You See Him |
| Buck Young | 2 | Make Me a Perfect Murder, A Bird in the Hand… |
| Clete Roberts | 2 | Dead Weight, Candidate for Crime |
| Dabney Coleman | 2 | Double Shock, Columbo and the Murder of a Rock Star |
| Danny Wells | 2 | A Deadly State of Mind, Forgotten Lady |
| Darrell Zwerling | 2 | Mind Over Mayhem, An Exercise in Fatality |
| David Byrd | 2 | Murder, A Self Portrait, No Time to Die |
| Dean Stockwell | 2 | The Most Crucial Game, Troubled Waters |
| Deidre Hall | 2 | Mind Over Mayhem, Columbo Cries Wolf |
| Don Calfa | 2 | Rest in Peace, Mrs. Columbo, Strange Bedfellows |
| Don Diamond | 2 | Candidate for Crime, Mind Over Mayhem |
| Don Keefer | 2 | Death Lends a Hand, The Most Crucial Game |
| Dorothy Dells | 2 | Now You See Him, Fade in to Murder |
| Ed Begley Jr. | 2 | How to Dial a Murder, Undercover |
| Elizabeth Lambert | 2 | Sex and the Married Detective, Death Hits the Jackpot |
| Frank Baker | 2 | Prescription: Murder, Murder by the Book |
| Frank Baxter | 2 | Lady in Waiting, Fade in to Murder |
| George Gaynes | 2 | Etude in Black, Any Old Port in a Storm |
| George Hamilton | 2 | A Deadly State of Mind, Caution: Murder Can Be Hazardous to Your Health |
| George Sawaya | 2 | Short Fuse, A Case of Immunity |
| George Skaff | 2 | A Case of Immunity, Make Me a Perfect Murder |
| George Sperdakos | 2 | Now You See Him, The Bye-Bye Sky-High I.Q. Murder Case |
| Ida Lupino | 2 | Short Fuse, Swan Song |
| James Gregory | 2 | Short Fuse, The Most Crucial Game |
| James McEachin | 2 | Etude in Black, Make Me a Perfect Murder |
| Jay Varela | 2 | Candidate for Crime, A Case of Immunity |
| Jean-Paul Vignon | 2 | Murder, A Self Portrait, Rest in Peace, Mrs. Columbo |
| Jeanette Nolan | 2 | Double Shock, The Conspirators |
| Jefferson Kibbee | 2 | Mind Over Mayhem, Swan Song |
| Joe Pine | 2 | Swan Song, A Case of Immunity |
| John Dehner | 2 | Swan Song, Last Salute to the Commodore |
| John McCann | 2 | Any Old Port in a Storm, The Conspirators |
| Joshua Bryant | 2 | A Friend in Deed, Last Salute to the Commodore |
| Joyce Van Patten | 2 | Negative Reaction, Old Fashioned Murder |
| Jude Farese | 2 | Candidate for Crime, An Exercise in Fatality |
| Judson Morgan | 2 | Ransom for a Dead Man, A Friend in Deed |
| Larry Burrell | 2 | Candidate for Crime, Swan Song |
| Larry Grant | 2 | Columbo Cries Wolf, Murder in Malibu |
| Lenny Hicks | 2 | Columbo Goes to the Guillotine, Murder, A Self Portrait |
| Leoda Richards | 2 | Murder by the Book, A Case of Immunity |
| Leslie Nielsen | 2 | Lady in Waiting, Identity Crisis |
| Lew Brown | 2 | Short Fuse, Candidate for Crime |
| Lucille Meredith | 2 | Candidate for Crime, Swan Song |
| Mariette Hartley | 2 | Publish or Perish, Try and Catch Me |
| Mark Russell | 2 | Prescription: Murder, Murder by the Book |
| Michael Fox | 2 | Etude in Black, The Most Dangerous Match |
| Michael Prince | 2 | The Conspirators, Death Hits the Jackpot |
| Michele Bernath | 2 | Murder in Malibu, It's All in the Game |
| Mickey Golden | 2 | Double Exposure, A Friend in Deed |
| Molly Hagan | 2 | Murder, Smoke and Shadows, Butterfly in Shades of Grey |
| Morris Buchanan | 2 | A Deadly State of Mind, Old Fashioned Murder |
| Murray Pollack | 2 | A Friend in Deed, A Case of Immunity |
| Norman Stevans | 2 | Swan Song, A Case of Immunity |
| Patrick O'Neal | 2 | Blueprint for Murder, Make Me a Perfect Murder |
| Penny Santon | 2 | Death Hits the Jackpot, Undercover |
| Ray Milland | 2 | Death Lends a Hand, The Greenhouse Jungle |
| Redmond Gleeson | 2 | A Deadly State of Mind, Now You See Him |
| Regis Cordic | 2 | Any Old Port in a Storm, Candidate for Crime |
| Richard Riehle | 2 | Ashes to Ashes, Murder With Too Many Notes |
| Robert Gibbons | 2 | Blueprint for Murder, Now You See Him |
| Robert Karnes | 2 | The Greenhouse Jungle, Candidate for Crime |
| Robert Rothwell | 2 | Double Shock, Death Hits the Jackpot |
| Robert Vaughn | 2 | Troubled Waters, Last Salute to the Commodore |
| Robin Bach | 2 | Rest in Peace, Mrs. Columbo, Columbo Goes to College |
| Rosanna Huffman | 2 | Suitable for Framing, Rest in Peace, Mrs. Columbo |
| Sondra Currie | 2 | Murder in Malibu, Columbo and the Murder of a Rock Star |
| Sorrell Booke | 2 | Swan Song, The Bye-Bye Sky-High I.Q. Murder Case |
| Stephen Elliott | 2 | A Deadly State of Mind, Grand Deceptions |
| Stuart Nisbet | 2 | Short Fuse, The Most Dangerous Match |
| Tim O'Connor | 2 | Double Shock, Old Fashioned Murder |
| Todd Martin | 2 | The Bye-Bye Sky-High I.Q. Murder Case, Murder Under Glass |
| Tyne Daly | 2 | A Bird in the Hand…, Undercover |
| Vincent J. McEveety | 2 | A Bird in the Hand…, It's All in the Game |
| Walker Edmiston | 2 | Dagger of the Mind, Any Old Port in a Storm |
| Wilfrid Hyde-White | 2 | Dagger of the Mind, Last Salute to the Commodore |
| William Bryant | 2 | Requiem for a Falling Star, Mind Over Mayhem |
| William Shatner | 2 | Fade in to Murder, Butterfly in Shades of Grey |
| William Windom | 2 | Prescription: Murder, Short Fuse |